| Full Form | Category | Term |
|---|---|---|
| SeAmless, Fixed-overhead Efficient (framing) | Computer and Networking | SAFE |
| Security and Freedom Through Encryption | Networking | SAFE |
| Simple Algorithm for Fragmentation Elimination | Softwares | SAFE |
| Secure Automated Financial Exchange | Accounts and Finance | SAFE |
| San Andreas Fault Experiment | Space Science | SAFE |
| Solar Array Flight Experiment | Space Science | SAFE |
| Sexual Assault Forensic Examiner | Job Title | SAFE |
| South American and Far East | Country Specific | SAFE |
| South Africa and Far East | Country Specific | SAFE |
| Simulated Atomic Fission Engine | Physics Related | SAFE |
| Smoke Alarms for Every Home | Real Estate | SAFE |
| Synthetic Agreement for Foreign Exchange | Stock Exchange | SAFE |
| Sun Air Food and Exercise | Sports | SAFE |
| Secure Analyst File Environment | Military and Defence | SAFE |
| Selected Area for Evasion | Military and Defence | SAFE |
| Safeguarding America for Everyone | Military and Defence | SAFE |
| Support To Analysis File Environment | Military and Defence | SAFE |
| Stay Alert for The Edge | Military and Defence | SAFE |
| Serve Accept Facilitate and Equip | Military and Defence | SAFE |
| Security and Freedom Enhanced | Military and Defence | SAFE |
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